Skip directly to content

About Bipolar Disorder

About Bipolar Disorder

Not an actual patient.

What is bipolar disorder?

Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, activity levels, and the ability to carry out day-to-day tasks. Bipolar disorder can be treated.

What are the different types of bipolar disorder?

There are different types of bipolar disorder. The type of bipolar disorder you have is determined by the kinds of episodes you experience.

  • Bipolar I disorder: Patients with bipolar I disorder have episodes of serious manic symptoms and deep depression
  • Bipolar II disorder: Patients with bipolar II disorder also have episodes of depression. But their manic episodes tend to have milder symptoms. This milder type of mania is also known as hypomania. GEODON is not approved to treat bipolar II disorder.

There are 3 types of episodes:


Periods of high moods (or “mania”). Symptoms of a manic episode may include feeling "high," having an extremely irritable mood, and restlessness; having racing thoughts or talking very fast; being easily distracted, or feeling little need for sleep.


A long period of feeling sad, worried or empty. Symptoms of a depressive episode may include loss of interest or pleasure in activities once enjoyed, including sex, and feeling tired or “slowed down”. GEODON is not approved to treat depressive episodes.


Feeling both manic and depressive symptoms. During a mixed state, symptoms often include agitation, trouble sleeping, major changes in appetite, and suicidal thinking. People in a mixed state may feel very sad or hopeless while feeling extremely energized.

Did you know?


If you have bipolar disorder, you’re not alone. Bipolar disorder has a prevalence of 1.8%. Bipolar disorder can run in families.


Usually, the first episode happens when a young person is in the late teens to early 20s. But it can also happen in young children and older adults.

Includes bipolar I, bipolar II, and bipolar disorder not otherwise specified. GEODON is only indicated for bipolar I disorder.

GEODON is available in 20-mg, 40-mg, 60-mg, and 80-mg capsules as well as in intramuscular injection in 20-mg/mL single-use vials.

GEODON Important Safety Information and Indications

WARNING:INCREASED DEATH IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSISGEODON® (ziprasidone HCl) is not approved for the treatment of patients with dementia-related psychosis. Elderly patients with dementia-related psychosis (having lost touch with reality due to confusion and memory loss) treated with this type of medicine are at an increased risk of death, compared to placebo
(sugar pill).

GEODON may increase the risk of changes to your heart rhythm. You should not take GEODON if you have certain kinds of heart conditions that change your heart rhythm, a recent heart attack, heart failure, or take certain medicines known to change heart rhythm. It is important to talk to your doctor about this possible side effect. Call your doctor right away if you faint, pass out, or feel a change in your heartbeat.

It is important to tell your doctor about any other medicines that you take, including non-prescription medicines, supplements, and herbal medicines.

If you experience a high fever, stiff muscles, shaking, confusion, sweating, or increased heart rate or blood pressure, tell your doctor right away. These can be signs of a rare but potentially fatal condition called neuroleptic malignant syndrome (NMS).

Delayed-onset drug reaction called Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) can occur with ziprasidone. Signs of DRESS may include rash, fever, and swollen lymph nodes. Other severe cutaneous adverse reactions (SCAR), such as Stevens-Johnson syndrome can occur with ziprasidone. Signs of Stevens-Johnson syndrome may include rash with blisters which could include ulcers in mouth, skin shedding, fever, and target-like spots in the skin. DRESS and other SCAR are sometimes fatal; therefore call your health care professional(s) and seek immediate care if you develop any of these signs or symptoms.

If you experience abnormal or uncontrollable facial or body movements, notify your doctor. These could be a sign of tardive dyskinesia (TD), a potentially permanent condition whose risk increases with the length of treatment, but which can also occur after brief periods at low doses.

If you have diabetes or have risk factors or symptoms of diabetes, your blood sugar should be monitored. Symptoms include excessive thirst, urination, appetite, and weakness. High blood sugar has been reported with GEODON and medicines like it. In some cases, extreme high blood sugar can lead to coma or death. Increases in cholesterol and weight gain have also been reported with medicines like GEODON.

Tell your doctor if you are pregnant or intend to become pregnant. Breastfeeding is not recommended.

Antipsychotic drugs (like GEODON) may cause drowsiness, dizziness, or lightheadedness upon standing which could lead to falls, fractures, or other injuries. If you experience these symptoms, tell your doctor.

If you experience a rash or seizures, tell your doctor. Also tell your doctor if you have thoughts of suicide.

Other risks may include decreases in white blood cells (which can be serious), trouble swallowing, high prolactin levels, and impairment in judgment or motor skills. Until you know how GEODON affects you, you should not drive or operate machinery.

Do not drink alcohol while taking GEODON. Avoid becoming overheated or dehydrated.

Common side effects of GEODON include:

  • Feeling unusually tired or sleepy
  • Nausea or upset stomach
  • Constipation
  • Dizziness
  • Restlessness
  • Abnormal muscle movements, including tremor, shuffling, and uncontrolled involuntary movements
  • Diarrhea
  • Rash
  • Increased cough/runny nose

In short-term bipolar mania clinical studies, 4.9% of GEODON-treated patients gained significant weight (7% or more of body weight) vs 3.3% for placebo.

In a long-term bipolar maintenance clinical study, patients who tolerated GEODON plus lithium or valproate (Depakote®) for 10-16 weeks were either continued on GEODON or switched to placebo for up to 6 months. During these six months, 5.6% of patients in both groups gained significant weight. These results do not include patients who did not complete the study.

In short-term schizophrenia clinical studies, 10% of GEODON-treated patients gained significant weight vs 4% for placebo.

Since there is no experience regarding the safety of administering GEODON for Injection to schizophrenic patients already taking oral GEODON, the practice of co-administration is not recommended.


GEODON is a type of prescription medicine called a psychotropic, also known as an atypical antipsychotic. GEODON can be used to treat symptoms of schizophrenia and acute manic or mixed episodes associated with bipolar disorder. GEODON can also be used as maintenance treatment of bipolar disorder when added to lithium or valproate. GEODON may increase the risk of changes to your heart rhythm. In some cases these types of changes can be fatal though it is unknown whether this is the case with GEODON. It is important to talk to your doctor about this potential side effect, as your doctor may consider a different medicine first.

Patients should always ask their doctors for medical advice about adverse events.

You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where health care professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit MedWatch or call 1-800-FDA-1088 .


*Terms and conditions apply. Card will be accepted only at participating pharmacies. Card is not health insurance. No membership fee.For more information, call 1-800-725-9655, visit, or write: Attn: GEODON Savings Card: 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560.

GEODON is a registered trademark of Pfizer Inc. Other brands listed are trademarks of their respective owners.

You are leaving

You are leaving this website. Links to all outside websites are provided as a convenience to our visitors and do not imply an endorsement or recommendation by Pfizer. Pfizer accepts no responsibility or liability for the content or services of other websites.